MULTIVARIATE MATHEMATICAL MORPHOLOGY FOR DCE-MRI IMAGE ANALYSIS IN ANGIOGENESIS STUDIES

Guillaume Noyel, Jesus Angulo, Dominique Jeulin, Daniel Balvay, Charles-André Cuenod

Abstract

We propose a new computer aided detection framework for tumours acquired on DCE-MRI (Dynamic Contrast Enhanced Magnetic Resonance Imaging) series on small animals. To perform this approach, we consider DCE-MRI series as multivariate images. A full multivariate segmentation method based on dimensionality reduction, noise filtering, supervised classification and stochastic watershed is explained and tested on several data sets. The two main key-points introduced in this paper are noise reduction preserving contours and spatio temporal segmentation by stochastic watershed. Noise reduction is performed in a special way to select factorial axes of Factor Correspondence Analysis in order to preserves contours. Then a spatio-temporal approach based on stochastic watershed is used to segment tumours. The results obtained are in accordance with the diagnosis of the medical doctors.

Keywords
classification; DCE-MRI series; multivariate mathematical morphology; segmentation; stochastic watershed; tumours

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DOI: 10.5566/ias.1109

Image Analysis & Stereology
EISSN 1854-5165 (Electronic version)
ISSN 1580-3139 (Printed version)