NUCLEI SHAPE ANALYSIS, A STATISTICAL APPROACH

Abstract

The method presented in our paper suggests the use of Functional Data Analysis (FDA) techniques in an attempt to characterise the nuclei of two types of cells: Cancer and non-cancer, based on their 2 dimensional profiles. The characteristics of the profile itself, as traced by its X and Y coordinates, their first and second derivatives, their variability and use in characterization are the main focus of this approach which is not constrained to star shaped nuclei. Findings: Principal components created from the coordinates relate to shape with significant differences between nuclei type. Characterisations for each type of profile were found.