NUCLEI SHAPE ANALYSIS, A STATISTICAL APPROACH
Keywords:2-dimensional profile, cancer detection, functional data analysis, principal differential analysis, star shape
AbstractThe method presented in our paper suggests the use of Functional Data Analysis (FDA) techniques in an attempt to characterise the nuclei of two types of cells: Cancer and non-cancer, based on their 2 dimensional profiles. The characteristics of the profile itself, as traced by its X and Y coordinates, their first and second derivatives, their variability and use in characterization are the main focus of this approach which is not constrained to star shaped nuclei. Findings: Principal components created from the coordinates relate to shape with significant differences between nuclei type. Characterisations for each type of profile were found.
How to Cite
Nettel-Aguirre, A. (2011). NUCLEI SHAPE ANALYSIS, A STATISTICAL APPROACH. Image Analysis & Stereology, 27(1), 1–10. https://doi.org/10.5566/ias.v27.p1-10
Original Research Paper