STEREOLOGY FOR THE WEIBEL-PALADE BODIES

Authors

  • Luis Manuel Cruz-Orive University of Cantabria (E-Santander)

DOI:

https://doi.org/10.5566/ias.4005

Keywords:

Hitting probabilities, motion invariant hitting measure, plane probe, right circular cylinder, slab probe

Abstract

Weibel-Palade (WP) bodies  are often rod shaped endothelial cell
organelles playing a role in blood coagulation processes. In 1962, E.R.
Weibel first observed a longitudinal transect of one such organelle  in
an electron micrograph, measuring about . He noticed that the a priori
probability of such an event --- analogous to that of hitting both ends
of a rod by a random plane --- should be "extremely low". The main
purpose of this note is to make an educated guess of that probability
--- more precisely, the expected proportion of transects affecting both
bases of a finite right circular cylinder, among all possible isotropic
and uniform random (IUR) transparent slabs, or planes, hitting the
cylinder.

References

Cruz-Orive LM (2017). Stereology: a historical survey. Image Anal

Stereol 36:153--177.

Cruz-Orive, LM (2024). Stereology. Theory and Applications.

Interdisciplinary Applied Mathematics 59. Cham: Springer Nature

Switzerland AG.

Fullman RL (1953) Measurement of approximately cylindrical particles in

opaque samples. J Metals/AIME Trans 197:1267--1268.

Gundersen (1979). Estimation of tubule or cylinder on thick sections. J

Microsc 117:333--45.

Howard CV, Reed MG (2005). Unbiased stereology. Three-dimensional

measurement in microscopy, 2nd ed, Oxford: Bios/ Taylor & Francis.

Miles RE, Davy PJ (1976). Precise and general conditions for the

validity of a comprehensive set of stereological fundamental formulae. J

Microsc 107:211--226.

Naveira AM, Reventos A, eds. (2009). Luis Antonio Santalo. Selected

Works. Berlin: Springer.

Santalo LA (1936). Geometria integral 7: Nuevas aplicaciones del

concepto de medida cinematica en el plano y en el espacio. Tesis

doctoral. Rev Acad Ci Madrid 33:451--504. [Reprinted in Naveira AM,

Reventos A, eds. (2009), pp. 167--212.]

Sterio DC (1984). The unbiased estimation of number and sizes of

arbitrary particles using the disector. J Microsc 134:127--36.

Valentijn KM, Sadler JE, Valentijn JA, Voorberg J, Eikenboom J (2011)

Functional architecture of Weibel-Palade bodies. Blood 117:5033--5043.

Weibel ER (2012a) Ewald Weibel: An organelle of his very own, and more.

People & Ideas, J Cell Biol 197:4--5.

Weibel ER (2012b) Fifty years of Weibel-Palade bodies: the discovery and

early history of an enigmatic organelle of endothelial cells. J Thromb

Haemost 10:979--984.

Weibel ER, Palade GE (1964) New cytoplasmic components in arterial

endothelia. J Cell Biol 23:101--112.

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Published

2026-06-17 — Updated on 2026-06-17

Data Availability Statement

Not made available to anyone.

Issue

Section

Original Research Paper

How to Cite

Cruz-Orive, L. M. (2026). STEREOLOGY FOR THE WEIBEL-PALADE BODIES. Image Analysis and Stereology. https://doi.org/10.5566/ias.4005